Bifida Ferment Lysate – Is this Skincare Ingredient the Next Big Thing?

Bifida ferment lysate, it’s a mouthful. What is it? Do you eat it, drink it, bathe in it? Here is your complete guide to everything you need to know about this skincare ingredient.

Skincare is self care – source

Keep reading to find out what bifida ferment lysate is, the benefits, risks, uses, and what products it is in today! Is bifida ferment lysate a super underrated superstar ingredient or is it all hype? Are there any scientific studies that prove the benefits of this ingredient? Let’s find out.

What is Bifida Ferment Lysate

Bifida ferment lysate is a probiotic-like ingredient made when bifida, a healthy bacteria, is fermented. It is an ingredient meant to work with the natural microbiota on top of the skin to help restore the health and look of the skin. It is not technically a probiotic, however, as the ingredient itself does not contain any live bacteria.


Allegedly, bifida ferment lysate helps with barrier function, decreases sensitivity in the skin, protects from UV ray damage from the sun, and helps hydrate the skin. There are also claims that it helps restore the skin barrier to full health. Remember that the skin is the largest organ in the body responsible for immune health, defending and protecting our insides from the outside world. A functioning skin barrier is essential not only to have good-looking skin but to increase overall health.

Science Behind it 

It is important to note that many of the current studies come from the main manufacturer themselves and from patents from the manufacturing company. This creates a conflict of interest that incentivizes studies that are favorable to be published. The studies included below reported no conflict of interest. Fortunately, it is a high-end company that is well known for creating effective, if expensive, skincare products. Find out who this company is below in the products section! 

This study documents that bifida ferment lysate is indeed protective against UV radiation. It even states that it can help protect against free radical damage.

Another study, not sponsored by a skincare company, found that when applied to the skin, the skin was less sensitive and less reactive to outside pollutants. This study, done in vitro, also found that bifida ferment lysate can strengthen the skin barrier, though human trials should be conducted.

How to Use Bifida Ferment Lysate

Bifida ferment lysate is commonly found in serums. This means it can be used either after cleansing the skin or after the use of a toner. Apply the serum and allow it to seep into the skin completely. Then, apply a moisturizer on top to seal in hydration and beneficial ingredients.

This skincare ingredient can also be in a cream, ampoule, or a toner, so the order in which you apply it depends on the product type. Here is a complete guide to knowing how to apply your skincare products to get the most bang for your buck, but listen to this hack.

In essence, you want to apply the product with the active ingredient that you need the highest concentration of first. This active ingredient is usually in a serum as you want it to penetrate deep into the skin.


Bifida ferment lysate is in the most iconic serum, the Estée Lauder Advanced Night Repair.  And boy does the price match the hype. At a whopping 85 dollars per ounce, it’s liquid gold in a bottle. Bifida ferment lysate in other high-end products too, such as Lancôme’s Génifique.

As an ingredient that needs to be studied more, it may be better to skip the high-end products altogether though. It can also be found in more affordable alternatives such as the Isntree  TW-Real Bifida Amoule.


There needs to be more research done into skin probiotics and fermented ingredients for the skin. The skin microbiome is complex and a lack of regulation in fermented products may result in an unbalanced skin microbiome. This can have damaging effects and may compromise one’s health.

The Takeaway

Bifida ferment lysate is an ingredient that has potential but needs more research behind it. Many products are using this ingredient, ranging from high-end to affordable. It may be a beneficial product if you have sensitive skin. Try it out and see if you like it! In any case, it seems to be a hydrating ingredient.

Health comes from within, so eat nutritious food, exercise when you can, and care for your mental health. Daily habits become building blocks for wellbeing and health. Remember to take care of microbiota health. Learn everything you need to know about gut microbiota today for free here.

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